We know that in season five Elena and Caroline are off to college.
Jeremy will now be Damon's room mate.
Bonnie is dead, the only one who can see her is Jeremy. So likely she will play a role still in Mystic Falls.
Matt and Rebekah have gone on a Euro trip. Matt has no plans so likely will continue to be a face in Mystic Falls at the bar and grill. Rebekah right now seems to be between both shows. If majority of time is with Mystic Falls. Likely she will also be part of the bar and grill with Matt.
Kathrine, also will spend time between time with shows. It seems through that she will be mainly part of the Mystic Falls plot line. An that means she will be in Mystic falls.
Silas, as Stefan or who ever he chooses to be. Likely will be Mystic Falls.
With that general outline of where the characters will be. I wonder what new characters and types will be introduced with and around Elena and Caroline at college. As the Mystic Falls seems still quite stocked with characters. As we still have the Mayor, sheriff, and April. To go with the others, along with the doctor Meredith. So I going to predict that the two girls will come in contact at college with a kitsune this season.
Anyone else have any ideas.