I personally have always thought it would be funny if after a big fight with Elena (over everything he's done recently) Damon vanished and in the next season they went looking for him (after a five year time skip or something) and when they found him he was living at a budhist monestary or something all zen like.
I think this would be funny because the idea of Damon acting all zen and in future stess full situations saying things like "You know perhaps as opposed to running around half blind our energies would be better spent on meditationg on the issue at hand."
I'd love to see everyone react to such a change in Damon. Especially if they started saying "I miss when Damon was a psycho and not a philsophical peace loving budhist."