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It should be possible. Hope is be wolf-witch hybrid but she has the vampire blood in her blood so she can become a tribrid when she dies and feeds on blood

I wish they had made Klaus a witch-werewolf hybrid in the flashbacks, or at least hinted at it. I suppose in general the werewolf gene is stronger than the witch one, so it's more likely the child is solely a werewolf. Who knows? Maybe there's a hint in the future that Freya and Keelin have another child and this time Keelin is the mother and Vincent is once again the donor, resulting in a witch-werewolf hybrid.