Beverly Jo Pryor is one of the Make-up Artists on The Vampire Diaries.
Pryor describes getting Ian Somerhalder and Paul Wesley into character as 'Vamp Mode.' It requires prosthetics, specially fitted fangs, and colored contact lenses. She also admits that there is some air brushing that takes place, not to mention special effects that help add to their frightening visage.
Other tricks are used for the attack scenes, such as fake necks. Pryor said that they even use special appliances to make up the gore and bites that are just another necessary ingredient to a show about vampires.